IgA deficiency during treatment of infantile hypothyroidism with thyroxine.

IgA deficiency during treatment of infantile hypothyroidism with thyroxine.

Serum IgA concentrations in five children with infantile hypothyroidism fell soon after the start of treatment with thyroxine. In one child the IgA concentration fell appreciably (to less than 0.01 g/1) and remained reduced; in the four others it returned to normal. IgM and IgG concentrations were roughly normal throughout. The deficiency in IgA concentrations may have been due to stimulation b...

Reversible IgA deficiency in hypothyroidism STEN ERIKSSON

A 50-year-old woman developed pronounced IgAdeficiency and hypothyroidism after 131I treatment for Graves' disease. The deficiency state was associated with a severe sinobronchial syndrome. Treatment with L-thyroxine resulted in a normal IgA concentration and a dramatic clinical improvement. Of the various possible underlying mechanisms, impaired synthesis of IgA light and heavy light chains se...

Reappraisal of thyroxine treatment in primary hypothyroidism.

The optimum daily dose of thyroxine was calculated for 13 children aged 3-16 years with primary hypothyroidism by titrating their doses at monthly intervals. The condition of the thyroid was assessed by sensitive assay of thyroid stimulating hormone concentrations, as well as measurement of total and free thyroid hormone concentrations and systolic time interval ratios. Serum thyroid stimulatin...

L-Thyroxine Treatment of Patients with Subclinical Hypothyroidism Reduce Inflammation

Background: Subclinical hypothyroidism (SCH) has been found to be associated with cardiovascular disease including atherosclerosis which is also called inflammatory disorder. The objective of this study was, to investigate the efficacy of L-thyroxine therapy on inflammation in patients with SCH and to determine whether treatment of SCH would reduce inflammation. Methods: Twenty patients with th...

Hypothyroidism, thyroxine treatment, and the heart.